DNBSEQ-T1+
/in MGI, Sequencing Platforms/by Harshita SharmaThe DNBSEQ-T1+ is one of the fastest T-level benchtop sequencers available globally—built on MGI’s proven DNBSEQ™ technology for accuracy, scalability, and reliability. Designed for clinical and translational genomics labs, the T1+ supports dual flow cell operation, delivering up to 1.2 terabases (Tb) of sequencing data within 24 hours (600 Gb per flow cell).
For laboratories managing time-sensitive or high-volume projects, this means faster turnaround, improved workflow efficiency, and reduced dependence on external bioinformatics infrastructure. The optional integrated bioinformatics module enables automated secondary analysis immediately after sequencing, helping clinicians and molecular pathologists move from raw data to interpretable results without delay.
In practice, DNBSEQ-T1+ helps streamline comprehensive genomic profiling (CGP), oncology testing, and clinical research pipelines—supporting both diagnostic accuracy and operational consistency across runs.
High-Speed, High-Throughput Sequencing
Generate up to 1.2 Tb of data in a single run with dual flow cell operation.
Choose from FCL, FCM, or FCS flow cells to match your throughput needs—from small clinical batches to large oncology cohorts.
Maintain >93% Q30 and >90% Q40 base quality across read lengths up to PE150.
Complete full runs in as little as 7–24 hours, supporting faster reporting and clinical turnaround.
Versatile Applications Across Clinical Genomics
Flexible read lengths (SE50–PE300) suit NIPT, RNA-Seq, oncology panels, WES, WGS, and methylation studies.
Supports coverage depth from 1 Gb to 120 Gb per sample, enabling both targeted assays and whole-genome workflows.
Ideal for translational and precision medicine—from pathogen detection to tumour profiling.
Integrated DNB Make & Load Technology
DNB M&L (Make & Load) module automates DNB preparation and loading directly within the sequencer.
Delivers consistent, contamination-free results with minimal hands-on time.
Each flow cell operates independently, supporting different read lengths or applications in parallel.
Enables an end-to-end “Make–Sequence–Analyse” workflow that saves time and reduces error.
Smart Configurations and Automated Analysis
Available in two setups: DNBSEQ-T1+ RS (flexible throughput) and T1+ ARS (with built-in bioinformatics).
The ARS configuration automatically triggers advanced data analysis post-run, streamlining bioinformatics pipelines.
Simplifies data interpretation for clinicians and molecular pathologists, improving workflow efficiency and diagnostic accuracy.
Chris Wicky
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The T1+ integrates seamlessly into oncology and comprehensive genomic profiling (CGP) pipelines, providing the depth and coverage needed for both solid tumour and liquid biopsy applications. With PE150 read lengths and up to 1.2 Tb per run, it supports multi-sample batching without compromising turnaround time.
Across all flow cell types, >93% of bases exceed Q30 and >90% exceed Q40, ensuring high-confidence variant detection for SNVs, indels, CNVs, and fusions. This level of consistency reduces the need for re-runs and strengthens the reliability of reported results.
Depending on the mode, runs complete within 7–24 hours, with automated secondary analysis available immediately post-run on the T1+ ARS configuration. This supports faster clinical reporting and improved patient turnaround.
The DNB Make & Load module automates DNB preparation within the sequencer, reducing manual steps, contamination risk, and hands-on time. Most labs can run end-to-end sequencing with minimal intervention after library prep.
Yes. Each flow cell operates independently, allowing different read lengths or applications—for example, running oncology panels alongside RNA-Seq or WES on the same instrument without downtime.