Twist Bioscience offers a revolutionary approach to synthetic DNA, enabling precise, high-quality oligos, genes, and NGS target enrichment panels at an unprecedented speed. Built on a proprietary silicon platform, Twist delivers DNA synthesis that is fully customizable, scalable, and cost-effective—helping genomics labs accelerate experiments without compromising accuracy or quality.
Whether you are designing complex panels, developing novel therapeutics, or conducting large-scale genomic studies, Twist’s solutions integrate seamlessly into your workflow. By reducing hands-on time and minimizing variability, the platform allows clinicians and researchers to focus on interpreting results, improving diagnostic confidence, and advancing patient care.
Twist delivers synthetic DNA that consistently meets specifications, giving you confidence in every experiment. ISO 13485:2016 certified for NGS target enrichment panels, reagents, and controls, the platform ensures reproducible results that enhance diagnostic accuracy and research reliability.
From early-stage research to industrial-scale projects, Twist’s solutions scale with your lab. Customize oligos, genes, or NGS panels to fit your specific needs, reducing time spent on sourcing and normalizing samples.
Save hours of hands-on time with high-throughput DNA synthesis. Faster turnaround allows you to focus on data interpretation, patient care decisions, or rapid project iteration—boosting overall workflow efficiency.
Twist’s intuitive ordering platform and dedicated customer support make it simple to incorporate synthetic DNA into daily lab routines. From procurement to troubleshooting, your team can operate smoothly without workflow disruptions.
Watch how Twist’s silicon-powered DNA synthesis platform transforms your workflow. Upload your sequence, receive instant synthesis predictions, optimize codons automatically, and get an instant quote—all with secure tracking from order to delivery. Visualize how our high-throughput, miniaturized process reduces hands-on time, increases scalability, and ensures reproducible, high-quality DNA for clinical and genomics applications.
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We know for you every minute and every data point matters. Twist Bioscience’s high-fidelity DNA synthesis accelerates your research and diagnostic workflows, enabling faster variant detection, streamlined NGS panel creation, and reproducible results that inform patient care. By minimizing sample variability and shortening turnaround times, you can focus on insights, not process—improving lab efficiency, reducing costs, and increasing confidence in clinical and research decisions.
Twist Bioscience isn’t just innovation—it’s validated performance. Across clinical and research labs, our silicon-powered DNA synthesis platform has consistently delivered high-throughput, reliable, and cost-efficient results. Explore our data to see how labs like yours have improved workflow efficiency, diagnostic accuracy, and research outcomes.
Twist Bioscience’s high-fidelity oligos enabled Phytoform Labs to accurately synthesize 2,000 AI-designed DNA sequences for wet-lab validation in tomato protoplasts.
Twist’s high-throughput genes helped Vanderbilt develop antibody candidates in under 60 days.
Twist Oligo Pools enabled the Baker Lab to design and screen thousands of novel proteins with higher experimental success rates.
Twist custom NGS panels enabled UC Berkeley researchers to explore the redwood genome and its link to survival and climate adaptation.
Twist technology enabled Dr. Leslie Lyons’ lab to decode feline mutations, supporting precision medicine for veterinarians worldwide.
Twist NGS tools enabled Universal Diagnostics to detect cancer early from just a 9 ml blood sample using methylation patterns.
MGFs range from 301–500 nucleotides, including flanking sequences used for PCR amplification. Flanks must be 20–25 bp, allowing up to 460 bp of variable coding region. Fragment length variation within a pool should not exceed 80 bp.
Twist MGFs are pooled double-stranded DNA fragments (301–500 bp) designed for high-throughput applications like prime editing, CRISPR functional screens, peptide/protein engineering, antibody discovery, and MPRA. This pooled format reduces cost per variant while enabling large-scale experiments.
Twist uses phosphoramidite chemistry on a miniaturized, high-throughput platform. This reduces reaction volumes and increases throughput, enabling pools up to 500 nt. Fragments are amplified into dsDNA via an optimized workflow for downstream applications.
Amplification ensures reliable dsDNA output and mitigates challenges associated with PCR amplification of synthesized material, improving consistency across experiments.
Remove signal leader peptides if using pTwist vectors with Twist-recommended signal leader.
Variable regions should not end with CH1 sequences.
Ensure sequences are divisible by three to match insertion sites.
Onboarding takes 10–15 business days from the assigned start date (once vector aliquot and completed form are received). Any unexpected issues are communicated promptly with a revised completion date.
Dried DNA: RT 3 months, 4°C 12 months, -20°C 24 months, -80°C long-term.
Resuspended DNA: Store in TE or elution buffer, not water. Use aliquots to minimize freeze-thaw cycles.
Gene Fragments: 100–1,000 ng per fragment.
Clonal Genes: Microprep 50 ng–2 µg, Miniprep 2–10 µg, Midiprep 10–100 µg, Maxiprep 100 µg–1 mg. Yield may vary based on sequence or vector; low-yield fragments still ship at no charge.
Clonal Genes: NGS-verified.
Gene Fragments: Not NGS-verified; sequencing 3–6 colonies (depending on fragment size) achieves 99% confidence in a perfect clone.
Each oligo is delivered at >0.2 fmol per oligo.
Customizable single-stranded DNA oligos (20–300 nt) synthesized with >90% uniformity and minimal dropout. High-quality pools support large-scale functional screens with an industry-leading error rate of 1:3,000.
Raise confidence in variant detection with superior target enrichment solutions
Precision, uniformity, and flexibility for results you can trust
Synthetic RNA and DNA standards for assay development
Identify more hits and streamline screening with Twist's precise Variant Libraries
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