Evercode WT

February 21, 2024/in Evercode, Parse, Partners/by Harshita Sharma

PRODUCTS

Evercode WT

Realize your single-cell aspirations with Evercode™ split-pool combinatorial barcoding. This straightforward, instrument-free solution revolutionizes single-cell sequencing, offering unparalleled sensitivity, scalability, and flexibility to labs of any size.

With Evercode™, you can effortlessly adopt a highly sensitive approach to single-cell sequencing, empowering you to unlock the complexities of cellular heterogeneity with ease. Scale your experiments to new heights while maintaining precision and reliability, thanks to Evercode’s adaptable design and seamless workflow.

Say goodbye to cumbersome instrumentation and complex protocols – Evercode™ simplifies single-cell sequencing, making it accessible to researchers at all levels. Whether you’re exploring the intricacies of developmental biology, investigating immune responses, or unraveling the mysteries of cancer heterogeneity, Evercode™ equips you with the tools you need to achieve your single-cell ambitions.

Higher Sensitivity with Evercode WT v2

Embark on a journey of unparalleled sensitivity in gene detection with Evercode WT v2. In a comprehensive comparative study conducted on mouse brain samples, Evercode WT v2 demonstrated remarkable superiority over the Chromium Next GEM Single Cell 3’ Kit v3.1. Remarkably, Evercode WT v2 detected an average of 84% more genes at a common read depth target of 20,000 reads per cell.

With Evercode WT v2 as your tool of choice, you can uncover a broader spectrum of genes and delve deeper into gene expression profiles. This invaluable information will enrich your research endeavors, providing nuanced insights into cellular dynamics and molecular processes. Elevate your single-cell transcriptomics studies to unprecedented heights with the unmatched sensitivity and precision offered by Evercode WT v2.

Boost the signal, reduce the noise

Elevate signal quality and minimize noise in your single-cell RNA sequencing (scRNA-seq) experiments with Evercode™. Multiplets, a common challenge in scRNA-seq approaches, can complicate data analysis and obscure biological insights. By adopting Evercode™, which utilizes a cell-as-reaction-vessel approach, you can eliminate issues associated with multiplets, leading to cleaner and more accurate data.

In a human-mouse species mixing experiment conducted with Evercode™, we achieved an exceptionally low multiplet rate of only 2.3%. This rate significantly outperforms traditional droplet-based approaches, demonstrating Evercode’s™ effectiveness in reducing multiplet interference and enhancing data quality.

With Evercode™, you can confidently boost signal detection while minimizing noise, enabling more precise and insightful analysis of single-cell transcriptomic data. Say goodbye to multiplet-related challenges and unlock the full potential of your scRNA-seq experiments with Evercode™.

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Evercode WT Mini

February 20, 2024/in Evercode, Parse, Partners/by Harshita Sharma

PRODUCTS

Evercode WT Mini

Introducing Evercode™ WT Mini V2, the revolutionary solution for single-cell whole transcriptome analysis. Designed to operate without the need for additional instruments, the Evercode™ WT Mini V2 allows you to delve into single-cell transcriptomics with ease and convenience.

Key features include:

Compact Design: The Evercode™ WT Mini V2 is perfectly sized for researchers looking to explore single-cell transcriptomics on a smaller scale. Its compact design makes it ideal for generating proof-of-concept results before scaling up to larger platforms.
Quality Results: Experience the exceptional quality of results achievable with Parse technology. The Evercode™ WT Mini V2 enables you to obtain reliable and accurate transcriptomic data from individual cells, providing valuable insights into your biological samples.
Scalability: As your research progresses, seamlessly transition to larger platforms such as the Evercode™ WT or Evercode™ WT Mega to delve deeper into your biology. The Evercode™ WT Mini V2 serves as an ideal starting point for expanding your single-cell transcriptomics studies.

With Evercode™ WT Mini V2, unlock the potential of single-cell transcriptomics and embark on a journey of discovery in your research. Explore the complexities of gene expression at the single-cell level and uncover new insights into cellular heterogeneity and biological processes.

Higher Sensitivity with Evercode WT v2

Experience unmatched sensitivity in gene detection with Evercode WT v2. In a comparative study conducted in mouse brain samples, Evercode WT v2 outperformed the Chromium Next GEM Single Cell 3’ Kit v3.1, detecting an average of 84% more genes at a common read depth target of 20,000 reads per cell.

With Evercode WT v2, you can uncover a broader spectrum of genes and gain deeper insights into gene expression profiles, providing invaluable information for your research endeavors. Elevate your single-cell transcriptomics studies to new heights with the superior sensitivity of Evercode WT v2

Lower multiplet rates than droplet-based approaches

Achieve significantly lower multiplet rates compared to droplet-based approaches with Evercode WT. In a human-mouse species mixing experiment utilizing Evercode WT, we observed an impressively low multiplet rate of only 2.3%. This rate is substantially lower than what is typically encountered with droplet-based methods.

By leveraging Evercode WT, researchers can confidently minimize the occurrence of multiplets, ensuring greater accuracy and reliability in single-cell transcriptomic analysis. This enhanced precision allows for more accurate interpretation of biological data and deeper insights into complex biological systems.

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OGM Data Services

February 19, 2024/in Bionano, Partners/by Harshita Sharma

PRODUCTS

OGM Data Services

USING OGM IN YOUR RESEARCH

Incorporating Optical Genome Mapping (OGM) into your research opens up a realm of possibilities for detecting genome-wide structural variations with unparalleled sensitivity and unbiased analysis. Unlike sequencing-based technologies and conventional cytogenetic techniques, OGM offers a comprehensive and highly sensitive approach to uncovering structural variations within the genome.

By leveraging our services laboratory, you can embark on projects to analyze samples using OGM. Our expert team will guide you through the process, ensuring accurate and reliable results. Whether you’re exploring genetic anomalies in cancer, investigating constitutional genetic disorders, or studying complex genomic rearrangements, OGM provides a powerful tool for uncovering structural variations with precision and efficiency.

With OGM, you can gain deeper insights into the genomic landscape of your samples, leading to breakthroughs in understanding disease mechanisms, identifying potential therapeutic targets, and advancing personalized medicine initiatives. Join us in harnessing the transformative potential of OGM to drive forward your research and uncover the hidden secrets of the genome.

HOW IT WORKS

During an Optical Genome Mapping (OGM) research project with our services laboratory, you’ll embark on a collaborative journey with our experienced team.

Here’s how it works:

Project Initiation: You’ll collaborate with our team to define the scope of your research project. Together, we’ll discuss your research question, objectives, and sample set selection.
Sample Analysis: Once the project scope is defined, our laboratory will perform OGM and initial structural variant analysis on your selected sample set. Using state-of-the-art technology and methodologies, we’ll generate high-quality data to address your research needs.
Collaboration and Communication: Throughout the project, we’ll maintain open communication channels to ensure that your research goals are met. We’ll provide regular updates on the progress of the analysis and seek your input as needed.
Data Delivery: At the conclusion of the project, you’ll receive comprehensive deliverables, including raw molecules data, assemblies, and annotated structural variant (SV) calls. Additionally, we’ll provide training on our proprietary visualization software, empowering you to explore and interpret the results effectively.
Data Integration: Our team will support you in integrating OGM results with other data types, such as sequencing and array data. We’ll facilitate exports to various file formats, including VCF files, enabling seamless comparison and combination of OGM results with other datasets.

Through this collaborative approach, we aim to deliver actionable insights that advance your research objectives and drive scientific discovery. Join us in unlocking the full potential of OGM to uncover the mysteries of the genome and accelerate breakthroughs in your field of study.

COMPARISON ANALYSIS

Structural variants called against GRCh37/hg19 or GRCh38/hg38 will be filtered against a control database or gene list of choice based on the project goals. Dual or trio variant annotation can be run for various applications. These include identifying de novo or inherited variants in germline samples, somatic variants in matched tumor-control samples, and targeted structural variants in edited versus unedited control cell lines. Just indicate the relationship between samples in the intake form.

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Compute Solutions

February 19, 2024/in Bionano, Partners/by Harshita Sharma

PRODUCTS

Compute Solutions

Experience comprehensive solutions for Optical Genome Mapping (OGM) data management and processing with Bionano Compute. Our suite encompasses a full spectrum of hardware, software, and cloud-based solutions, ensuring a seamless workflow from start to finish.

Bionano Compute offers end-to-end experiment management and bioinformatics processing, empowering researchers with robust tools for efficient data analysis. Additionally, it provides convenient management and monitoring tools tailored for the Saphyr™ and Stratys™ instruments, streamlining operations and enhancing productivity.

With Bionano Compute, researchers can harness the power of advanced technology to unlock insights from genomic data with unparalleled ease and efficiency.

The Stratys™ Compute high-performance workstation ensures seamless scalability for your workflow demands.

Fueled by NVIDIA RTX GPUs, it offers expedited runtimes and reduced compute costs, thanks to its cutting-edge technology. With each software release, expect accelerated performance, enhancing overall efficiency.

Experience unparalleled sensitivity in detecting all classes of structural variants (SVs) across the genome with the latest informatics pipeline tailored for Optical Genome Mapping (OGM) data.

Installed alongside the Stratys instrument, the Stratys Compute workstation minimizes IT burdens and implementation time, optimizing your setup for streamlined operations.

Reduce infrastructure costs and expand your Optical Genome Mapping (OGM) capacity effortlessly with Bionano Compute On Demand.

This pay-per-use solution, accessible via the Bionano Access web server for Bionano Solve operations, revolutionizes OGM data analysis from the Saphyr™ or Stratys™ instruments without necessitating additional infrastructure. Enjoy the flexibility and scalability your experiments demand with Compute On Demand.

Key advantages of Compute On Demand include:

Analyze large genomes and numerous samples simultaneously, maximizing throughput and efficiency.
Perform pipeline analysis operations seamlessly, without concerns about server capacity constraints.
Safeguard data integrity with encryption measures, ensuring secure operations and compliance with data protection regulations.
Maintain data center compliance with IPAA, CSA, SOC2, and ITAR regulations, guaranteeing adherence to industry standards and regulations.

With Bionano Compute On Demand, unlock the full potential of your OGM experiments while optimizing costs and maintaining data security and compliance.

Experience high-speed, on-site Optical Genome Mapping (OGM) data processing tailored for the Saphyr™ with the Saphyr™ Compute Server.

This compact solution delivers cluster-like performance at an affordable cost, revolutionizing your data analysis capabilities.

Key features of the Saphyr™ Compute Server include:

Cluster-like Performance: Enjoy the power of multiple simultaneous analyses and sustained throughput, reducing downtime and accelerating your research.
Rapid Analysis: Perform rare variant analysis and annotation of a human genome in approximately nine hours, enabling swift insights into complex genomic structures.
User-Friendly Interface: Seamlessly integrate the Saphyr™ Compute Server into any network setup with its simple web-based interface, ensuring compatibility and ease of use.

With the Saphyr™ Compute Server, spend less time waiting for data and more time delving into meaningful results, advancing your research endeavors with unparalleled efficiency and speed.

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Sample Preparation Kits

February 19, 2024/in Bionano, Partners/by Harshita Sharma

PRODUCTS

Sample Preparation Kits

Effortlessly prepare samples for Optical Genome Mapping (OGM) with Bionano’s comprehensive Sample Preparation Solutions, ensuring accurate identification of structural variants.

OGM necessitates labeled ultra-high molecular weight (UHMW) DNA, and Bionano offers a diverse range of DNA sample prep kits designed for simple and reliable isolation of UHMW DNA from various sample types. Once DNA isolation is complete, our Direct Label and Stain (DLS) kits can efficiently label DNA for compatibility with the Saphyr system.

With our Generation 2 Kits, featuring robust enhancements and optimizations to the sample preparation OGM workflow, you can achieve sample-to-answer results in just 3 to 4 days! Experience accelerated and streamlined sample preparation, paving the way for enhanced genomic analysis and structural variant detection.

Attain robust isolation and labeling of Ultra-High Molecular Weight (UHMW) DNA, crucial for visualizing large genomic structural variants.

Bionano’s innovative Solution Phase (SP) technology facilitates the isolation of DNA fragments exceeding 1 Megabase pair (Mbp) in length, consistently yielding average fragments surpassing 230 kilobase pairs (kbp).

To contextualize, while short-read sequencing generates reads up to 150 base pairs (bp) in length, even leading high-accuracy long-read sequencing methods offer read lengths limited to approximately 25 kilobases (kb). Bionano’s SP technology surpasses these limitations, enabling the analysis of genomic structural variants with unprecedented detail and accuracy.

Extract DNA from a diverse array of crucial sample types effortlessly with the latest Bionano SP DNA prep kits.

These kits excel at purifying Ultra-High Molecular Weight (UHMW) DNA from tissues, tumors, bone marrow aspirate (BMA), blood, cells, as well as various plant and animal tissues. This versatility makes Optical Genome Mapping (OGM) applicable across a wide spectrum of studies and applications, including oncology, constitutional genetic disease research, bioprocessing, and general scientific inquiry.

Bionano’s SP kits necessitate 1.5 * 10^6 cells (for blood, cell lines, and BMA) or 10 – 30 mg of tissue as input. Employing a lyse, bind, and wash process along with novel paramagnetic disks, these kits enable the isolation of UHMW DNA in approximately four hours. This streamlined workflow ensures efficient extraction of high-quality DNA, empowering researchers across various fields to unlock the mysteries of the genome with ease.

Boost your workflow throughput by integrating the efficiency of automation.

Through a pioneering collaboration with the Hamilton Company, Bionano presents the groundbreaking Long String Star V – the world’s inaugural automated platform tailored for the isolation of Ultra-High Molecular Weight (UHMW) DNA.

The Long String Star V stands as an assay-ready workstation, harmoniously designed to complement Bionano’s G2.LS DNA Isolation kits. With this innovative platform, a single operator can seamlessly extract UHMW DNA from up to 24 samples per day, revolutionizing sample processing efficiency while maintaining high-quality results. Experience unparalleled productivity and precision as you propel your research forward with the Long String Star V automation system.

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Stratys

February 19, 2024/in Bionano, Partners/by Harshita Sharma

PRODUCTS

Stratys

Elevate the OGM Sample-to-Report Workflow with the Stratys™ System

Embark on a revolutionary journey towards enhanced workflow speed and simplicity by leveraging the power of Optical Genome Mapping (OGM) combined with the cutting-edge Bionano Stratys™ System. With this innovative approach, break free from the limitations of conventional cytogenetics and sequencing techniques, as you delve into the comprehensive detection of all classes of structural variants. Experience a paradigm shift in genetic analysis, where efficiency and precision converge to unlock new realms of understanding within the genome.

*Lower VAF percentages can be achieved when using the Stratys Plus Chip, which enables up to 1200x genome coverage.

STRATYS CHIPS

Experience unparalleled efficiency and tailored performance with STRATYS CHIPS – your gateway to optimized reagents and consumables for diverse applications. Tailor your journey to results with a versatile array of chips meticulously crafted to align with your unique requirements. Within the STRATYS chips, immerse DNA molecules in a precise nanofluidic environment, where they seamlessly linearize across hundreds of thousands of nanochannels. Through advanced imaging, unravel the intricate genomic architecture and uncover subtle structural variations with unparalleled clarity and accuracy.

STRATYS COMPUTE

Maximize workflow efficiency with STRATYS COMPUTE, your solution for streamlined data processing, ensuring a seamless flow of operations.

Data Processing Powerhouse: Powered by NVIDIA RTX GPUs, STRATYS COMPUTE boasts remarkable processing power, enabling significantly faster runtimes and reduced compute costs. Leveraging cutting-edge technology, software releases drive acceleration, enhancing overall performance.

Support a Constant Flow of Data: Benefit from STRATYS COMPUTE’s advanced technology and intelligent processing, facilitating a continuous stream of data from the Stratys instrument. This ensures optimal scalability of your workflow, maintaining productivity at scale.

Best Sensitivity for OGM: Equipped with the latest informatics pipeline for Optical Genome Mapping (OGM) data, STRATYS COMPUTE delivers unparalleled sensitivity for genome-wide detection of all classes of structural variants (SVs) using OGM technology.

Minimal IT Resources Required: Designed for ease of implementation, the STRATYS COMPUTE workstation can be conveniently installed alongside the Stratys instrument without the need for a dedicated data center. This reduces IT overhead and minimizes implementation time, ensuring a hassle-free setup process.

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Saphyr

February 19, 2024/in Bionano, Partners/by Harshita Sharma

PRODUCTS

Saphyr

Reveal genome-wide structural variation with the Saphyr™ optical genome mapping system.

Consistently identify structural variants across all classes with a resolution as low as 500 base pairs (bp) and a variant allele frequency (VAF) as low as 5% utilizing optical genome mapping (OGM) through the Saphyr™ system. Saphyr™ stands as the foremost tool for detecting structural variants, surpassing the capabilities of next-generation sequencing (NGS) methods and traditional cytogenetic approaches, thus capturing genomic variations often overlooked by these technologies.

Achieve broad, unbiased genomic coverage with flexible data collection.

The Saphyr™ system offers adaptable genomic coverage, enabling the identification of heterozygous or infrequent variants present in mosaic samples and heterogeneous tumors.

In just six hours, obtain a comprehensive 100X coverage of a human genome. To uncover deeper and rarer variants, merely prolong the data collection time on Saphyr™ without incurring additional consumable costs. Achieve an impressive 400X coverage within a 24-hour period, facilitating structural variant (SV) detection down to a 5% variant allele frequency (VAF). Extend runtime further to explore variants with even lower VAF levels.

Enjoy seamless integration and workflow efficiency with the Saphyr™ Chip® consumable and Saphyr™ system.

The Saphyr Chips feature hundreds of thousands of highly parallel nanochannels, which efficiently linearize long, labeled DNA molecules, enabling direct imaging of your samples by the Saphyr instrument.

Sample loading onto the Saphyr Chip is swift and straightforward. Easily pipette up to three samples into individual flow cells on the chip. With the capability to load up to two chips onto the Saphyr instrument per run, achieve a maximum throughput of six samples per operation.

Benefit from the Saphyr instrument and chips’ integration of machine learning-based adaptive loading and automatic run optimization. These features ensure hassle-free scanning and optimize throughput speed, allowing for walk-away operation and the fastest achievable throughput for each run.

Guarantee optimal performance through automated health system monitoring accessible remotely.

The Saphyr™ Assure Service offers an optional (opt-in) automated health monitoring feature, which consistently evaluates data quality and instrument functionality. This feature detects potential issues before they impact data quality and performance, enabling Bionano Support to proactively address any concerns and conduct necessary repairs with minimal downtime.

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Franklin

January 30, 2024/in Genoox, Partners/by Harshita Sharma

PRODUCTS

Franklin

Introducing Franklin – a groundbreaking initiative that seamlessly integrates public data sets with real-world evidence, revolutionizing clinical diagnosis, expediting clinical reporting, ensuring consistent classification, all while fostering a thriving community of genomic professionals and upholding data sovereignty and security.

Impacting Lives at the
Point of Care

Your Gateway to the
Actionable Genome

The Power of
Community

Actionable Insights: With Franklin, genomic professionals can redirect their focus from navigating evidence to delving into actionable insights. Our mission is to construct the most extensive and diverse real-world evidence dataset, unlocking answers to any genomic query through the collaborative power of the community, data, and insights.

Franklin’s Community: Who makes up the Franklin community? Our genomic professionals hail from every facet of the medical genetics domain and span the globe. From genetic counselors, expert physicians, and oncologists to variant scientists, bioinformaticians, clinical geneticists, researchers, and pharmacologists, Franklin unites a diverse array of specialists dedicated to advancing genomic knowledge and practice.

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Our team at Decode Science can help connect you with the experts at Genoox, to arrange a customised demo for your group.

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DNBSEQ-E25

January 29, 2024/in MGI, Partners, Sequencing Platforms/by Harshita Sharma

PRODUCTS

DNBSEQ-E25

DNBSEQ-E25 : Sequence Your Samples On-The-Go

Embark on a streamlined sequencing journey from sample to report with the DNBSEQ-E25 sequencer. This compact and standalone system is designed to operate effortlessly inside or outside the lab, providing versatility in its usage. The E25 seamlessly integrates a microfluidic chip, an integrated CMOS detection module, self-luminous dye, and a proprietary computing module. This harmonious combination results in a lightweight and cost-effective instrument that breaks free from location restrictions, allowing you to conduct sequencing processes with ease and efficiency. The DNBSEQ-E25 is your solution for convenient and accessible sequencing wherever you need it.

Plug-And-Play

Experience seamless and hassle-free sequencing with our plug-and-play solution. The DNBSEQ-E25 incorporates an integrated microfluidic sequencing chip with a CMOS detection module underneath each spot. This innovative design minimizes environmental sensitivity, reduces costs, and lightens the weight of the sequencer. The result is a truly plug-and-play system, streamlining the sequencing process and providing you with an efficient and user-friendly solution for your research needs.

Data Analysis Has Never Been Easier

Simplify your data analysis process with the DNBSEQ-E25, where efficiency meets ease. The advanced model, DNBSEQ-E25A, takes it a step further by incorporating an enhanced computing module capable of running data analysis for various applications, including whole-genome sequencing. These sequencing platforms operate as standalone systems, managing the entire workflow from sample to result without the need for a network connection. This not only ensures ease of use but also eliminates the risk of data breaches, providing you with a secure and reliable solution for your sequencing needs.

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DNBSEQ-G400

January 29, 2024/in MGI, Partners, Sequencing Platforms/by Harshita Sharma

PRODUCTS

DNBSEQ-G400

DNBSEQ-G400 : Your Day-to-Day Sequencing Solution

Elevate your day-to-day sequencing experience with the DNBSEQ-G400, your comprehensive sequencing solution. This system offers a versatile range of sequencing options, accommodating read lengths of up to SE400/PE300 and supporting two flow cell types. With built-in primary data analysis and optimized optical and biochemical systems, the DNBSEQ-G400 ensures a seamless and efficient sequencing process for your daily research needs. Trust in this innovative solution to deliver reliable and high-quality results, making it an essential tool for your routine sequencing endeavors.

Features

The sequencing platform offers a broad data output range of 55 Gb to 1440 Gb per run, with PE150(FCS) sequencing achieving full capacity in just 37 hours. It supports various read lengths, including SE50, SE100, SE400, PE100, PE150, PE200, and PE300. The platform’s versatility extends to diverse applications, encompassing basic research, clinical research, forensics, and agriculture, making it suitable for a wide range of scientific and investigative endeavors.

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Evercode WT

100K CELLS

48 SAMPLES

EXPONENTIALLY SCALABLE

NO INSTRUMENT REQUIRED

UNMATCHED DATA QUALITY

WORKS WITH FIXED CELLS AND NUCLEI

Let’s Find You an Application That Helps Your Research

Evercode WT Mini

10K CELLS

12 SAMPLES

EXPONENTIALLY SCALABLE

NO INSTRUMENT REQUIRED

UNMATCHED DATA QUALITY

WORKS WITH FIXED CELLS AND NUCLEI

Let’s Find You an Application That Helps Your Research

OGM Data Services

HOW IT WORKS

COMPARISON ANALYSIS

Let’s Find You an Application That Helps Your Research

Compute Solutions

Let’s Find You an Application That Helps Your Research

Sample Preparation Kits

Let’s Find You an Application That Helps Your Research

Stratys

500 bp

5%

12 Samples

1200x

Let’s Find You an Application That Helps Your Research

Saphyr

Let’s Find You an Application That Helps Your Research

Franklin

Impacting Lives at the Point of Care

Your Gateway to the Actionable Genome

The Power of Community

Let’s Find You an Application That Helps Your Research

DNBSEQ-E25

Plug-and-Play

Efficient

Hassle-free

Have a question?

DNBSEQ-G400

Accurate

Versatile

Flexible

Have a question?

APPLICATIONS

PARTNERS

COMPANY

SUPPORT

EXPONENTIALLY
SCALABLE

NO INSTRUMENT
REQUIRED

EXPONENTIALLY
SCALABLE

NO INSTRUMENT
REQUIRED

Impacting Lives at the
Point of Care

Your Gateway to the
Actionable Genome

The Power of
Community