1300 581 991

Get In Touch
Report a Bug
Search
Close this search box.
Twitter Linkedin-in

Huber, H., Montoliu-Gaya, L., Brum, W.S. et al. A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology. Nat Med (2026). https://doi.org/10.1038/s41591-025-04080-0

Simoa Dry Blood Extraction Kit

The Simoa Dry Blood Extraction Kit is a validated, device-agnostic solution for extracting analytes from dried plasma and dried blood spot (DPS/DBS) samples for use with Simoa® assays. It enables consistent, reproducible recovery of low-abundance biomarkers while maintaining the femtogram-level sensitivity required for clinical and translational research.

Designed to support decentralized and remote sample collection, the kit simplifies pre-analytical workflows without compromising data quality. It is well suited for longitudinal studies, multi-site trials, and settings where traditional venous sampling and cold-chain logistics are impractical.

Read the DROP AD Study
Key Features of the Simoa Dry Blood Extraction Kit

Device-agnostic compatibility

Validated across multiple dried plasma and dried blood spot collection devices, enabling consistent analyte recovery independent of collection format. This supports reliable data generation across decentralized, remote, and longitudinal study designs.

Standardized, semi-automated workflow

A harmonized extraction protocol controls critical pre-analytical variables, including elution conditions, centrifugation parameters, and buffer composition. This reduces operator- and site-dependent variability and improves reproducibility across batches and study sites.

Preservation of analytical sensitivity

The extraction process is optimized to maintain the ultra-high sensitivity of Simoa® assays, enabling reliable detection of low-abundance biomarkers such as p-Tau 217. Suitable for neurological, inflammatory, and systemic biomarker applications where signal integrity is critical.

Direct compatibility with Simoa® assays

Designed specifically for downstream use with Simoa® kits, the workflow integrates into existing laboratory processes without the need for additional assay optimization or protocol development.

Clinical Evidence: DROP-AD Study (Nature Medicine)

Hanna Huber
Nutrition Scientist // Ph.D // Postdoctoral researcher @DZNE Bonn & University of Gothenburg

The Simoa Dry Blood Extraction Kit workflow is supported by evidence from the DROP-AD study, published in Nature Medicine, demonstrating that capillary dried blood samples can be used to reliably quantify key Alzheimer’s disease biomarkers.

The multi-centre European study showed strong concordance between capillary dried blood and conventional venous plasma measurements for:

  1. p-Tau217 – strong correlation across multiple sites

  2. GFAP and NfL – reliable quantification with high plasma concordance

The approach demonstrated good diagnostic accuracy for identifying CSF-confirmed Alzheimer’s pathology and high reproducibility with self-collected samples, supporting decentralized and remote study designs.

Importantly, the study confirms the feasibility of this approach in high-risk and underrepresented populations, including individuals with Down syndrome, and eliminates the need for venipuncture, centrifugation, and cold-chain logistics.

This workflow is intended for research use only and is not designed for clinical diagnosis or clinical decision-making.

Instant Download Simoa Dry Blood Extraction Kit Tech Note

Unlock with quick sign up!

    DOWNLOAD TECH NOTE >
    Designed for Real-World Clinical and Research Workflows

    The Simoa Dry Blood Extraction Kit is designed to support high-sensitivity biomarker analysis in settings where traditional venous sampling and cold-chain logistics are limiting.

    For academic and translational neuroscience teams conducting large cohort or longitudinal studies, the kit provides a standardized method for extracting biomarkers from small-volume, remotely collected samples, reducing pre-analytical variability and improving inter-site comparability.

    In pharmaceutical and biotechnology research, the workflow supports early-phase and decentralized study designs where sample volume is limited but analytical sensitivity is critical.

    For public health and global research settings, the kit enables reliable laboratory-grade biomarker analysis from capillary dried blood samples, supporting studies in low-resource or geographically distributed populations.

    Applications and Intended Use

    The Simoa Dry Blood Extraction Kit is intended for the extraction of analytes from capillary-derived dried blood and plasma collection devices to support detection of low-abundance biomarkers using Simoa® assay kits.

    For research use only.

    Kit Contents

    Each kit includes Quanterix extraction buffer and two precipitation plates.

    Julia Young

    Quanterix Business Manager

    As the official distributor of Quanterix in Australia and New Zealand, Decode Science is providing local access to Simoa® platforms, assays, and workflow solutions with region-based technical and application support.

    Get In Touch Today
    Related Products

    Simoa® Ultra-sensitive Biomarker Detection in Dried Blood and Plasma Spots for Alzheimer’s Disease

    VIEW WHITEPAPER >

    Dried Plasma Spots (DPS) Coupled with Ultra-sensitive Biomarker Detection – Advancing Alzheimer’s Biomarker Testing

    VIEW STUDY >

    p-Tau 217 (Simoa® ALZpath) Assay: A Key Biomarker in Alzheimer’s Disease

    VIEW PRODUCT >

    Quanterix Portfolio

    SR-X™ Biomarker Detection
    System

    HD-X™ Automated Immunoassay Analyzer

    • Decode Science Pty Ltd
      Level 1, 2-12 Allen St,
      Wellington 6011
      Phone: 0800 DECODE (332633)
    • support@decodescience.co.nz
    Decode Science Terms of Sale

    APPLICATIONS

    PARTNERS

    COMPANY

    SUPPORT

    Instant Download

    Simply add your details below and get quick access to the brochure.

      You agree to receive communications from Decode Science.View Our Privacy Policy.

      Instant Download

      Simply add your details below and get quick access to the brochure.

        You agree to receive communications from Decode Science.View Our Privacy Policy.

        Instant Download

        Simply add your details below and get quick access to the brochure.

          You agree to receive communications from Decode Science.View Our Privacy Policy.

          Special October Offer

          FREE UMBRELLA

          ORDER NOW